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ea0035p813 | Paediatric endocrinology | ECE2014

Polycystic ovary syndrome in overweight and obese adolescent girls and its association with insulin resistance and metabolic syndrome

Smetanina Natalija , Valickas Raimondas , Seibokaite Audrone , Verkauskiene Rasa

Background: The prevalence of polycystic ovary syndrome (PCOS) in adolescents is reported up to 38.9%. Obesity is a known risk factor associated with PCOS increasing the risk of metabolic syndrome (MS). Up to 25% of adolescents with PCOS may have derangements in glucose metabolism and insulin resistance (IR).Aim: To evaluate PCOS prevalence in overweight/obese adolescent girls and to assess the association with BMI, MS and IR.Metho...

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ea0035p931 | Pituitary Clinical (<emphasis role="italic">Generously supported by IPSEN</emphasis>) | ECE2014

Population-based cohort study: PROP1 gene mutations are the most prevalent cause of congenital multiple pituitary hormone deficiency in Lithuania

Navardauskaite Ruta , Dusatkova Petra , Obermannova Barbora , Pfaeffle Roland W , Blum Werner F , Adukauskiene Dalia , Smetanina Natalija , Cinek Ondrej , Verkauskiene Rasa , Lebl Jan

Introduction: Congenital multiple pituitary hormone deficiency (MPHD) may result from defects of transcription factors that govern the early pituitary development. The most prevalent are two mutation of PROP1 gene: the c.296delGA and c.150delA.Methods: Seventy-five Lithuanian MPHD patients were tested for PROP1 defects. Perinatal and postnatal data were obtained from medical records. Hormonal investigations, pituitary imaging and GH the...

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Endocrine Abstracts

Polycystic ovary syndrome in overweight and obese adolescent girls and its association with insulin resistance and metabolic syndrome

Population-based cohort study: PROP1 gene mutations are the most prevalent cause of congenital multiple pituitary hormone deficiency in Lithuania

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